4uf1

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Deerpox virus DPV022 in complex with Bak BH3

Structural highlights

4uf1 is a 2 chain structure with sequence from Deerpox virus W-1170-84 and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:SO4
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPV22_DPV83 Plays a role in the inhibition of host apoptosis by sequestering and inactivating several proapoptotic BCL-2 proteins, including BAK1 and BAX. Prevents the conformational activation of both of them.[1]

References

  1. ↑ Banadyga L, Lam SC, Okamoto T, Kvansakul M, Huang DC, Barry M. Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. J Virol. 2011 Mar;85(5):1922-34. PMID:21159883 doi:10.1128/JVI.01959-10

Contents


PDB ID 4uf1

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OCA

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