Structural highlights
4uqg is a 3 chain structure with sequence from Geobacillus stearothermophilus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
E1C9K5_GEOSE
Publication Abstract from PubMed
We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.
"Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link.,Tomas-Gamasa M, Serdjukow S, Su M, Muller M, Carell T Angew Chem Int Ed Engl. 2014 Nov 28. doi: 10.1002/anie.201407854. PMID:25446281[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Tomas-Gamasa M, Serdjukow S, Su M, Muller M, Carell T. "Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link. Angew Chem Int Ed Engl. 2014 Nov 28. doi: 10.1002/anie.201407854. PMID:25446281 doi:http://dx.doi.org/10.1002/anie.201407854
