5fcl

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Crystal structure of Cas1 from Pectobacterium atrosepticum

Structural highlights

5fcl is a 6 chain structure with sequence from Pectobacterium atrosepticum SCRI1043. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAS1_PECAS CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).[1]

See Also

References

  1. ↑ Vercoe RB, Chang JT, Dy RL, Taylor C, Gristwood T, Clulow JS, Richter C, Przybilski R, Pitman AR, Fineran PC. Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands. PLoS Genet. 2013 Apr;9(4):e1003454. doi: 10.1371/journal.pgen.1003454. Epub 2013 , Apr 18. PMID:23637624 doi:http://dx.doi.org/10.1371/journal.pgen.1003454

Contents


PDB ID 5fcl

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OCA

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