5ilz

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Tobacco 5-epi-aristolochene synthase with BIS-TRIS propane (BTP) buffer molecule

Structural highlights

5ilz is a 1 chain structure with sequence from Nicotiana tabacum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.92Å
Ligands:B3P
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

5EAS_TOBAC Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.

See Also

Contents


PDB ID 5ilz

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OCA

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