5ipi
From Proteopedia
Structure of Adeno-associated virus type 2 VLP
Structural highlights
FunctionCAPSD_AAV2S Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.[1] [2] [3] [4] See AlsoReferences
|
Categories: Adeno-associated virus 2 | Large Structures | Agbandje-McKenna M | Baker TS | Bennet A | Cardone G | Chen W | Chipman P | Drouin LM | Janssen ME | Lins B | McKenna R | Muzyczka N