5jaw

From Proteopedia

Structure of a beta galactosidase with inhibitor

Structural highlights

5jaw is a 8 chain structure with sequence from Cellvibrio japonicus Ueda107. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Ligands:	ACT, NA, UUU
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B3PBE0_CELJU

Publication Abstract from PubMed

Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of beta-glucosidases and beta-galactosidases.

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.,Schroder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codee JDC, van der Marel GA, Overkleeft HS Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k. PMID:29116266^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

1 reviews cite this structure

Current methods to analyze lysosome morphology, positioning, motility and function.

Barral et al. (2022)

0 more

14 other articles

No citations found

References

↑ Schroder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codee JDC, van der Marel GA, Overkleeft HS. Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines. Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k. PMID:29116266 doi:http://dx.doi.org/10.1039/c7cc07730k

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

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PDB ID 5jaw

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Categories: Cellvibrio japonicus Ueda107 | Large Structures | Davies G | Offen W

5jaw

From Proteopedia

Structure of a beta galactosidase with inhibitor

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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