5l8d

From Proteopedia

X-ray structure of NikA from Escherichia coli in complex with Ru(bis(pyrzol-1-yl)acetate scorpionate)(CO)2Cl

Structural highlights

5l8d is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	6RP, ACT, CL, CMO, EDT, FE, GOL, RU, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NIKA_ECOLI Involved in a nickel transport system, probably represents the nickel binder.

Publication Abstract from PubMed

Artificial enzymes are required to catalyse non-natural reactions. Here, a hybrid catalyst was developed by embedding a novel Ru complex in the transport protein NikA. The protein scaffold activates the bound Ru complex to produce a catalyst with high regio- and stereo-selectivity. The hybrid efficiently and stably produced alpha-hydroxy-beta-chloro chlorohydrins from alkenes (up to 180 TON with a TOF of 1050 h-1).

Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme.,Lopez S, Rondot L, Cavazza C, Iannello M, Boeri-Erba E, Burzlaff N, Strinitz F, Jorge-Robin A, Marchi-Delapierre C, Menage S Chem Commun (Camb). 2017 Mar 23;53(25):3579-3582. doi: 10.1039/c6cc08873b. PMID:28289745^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

reviews cite this structure

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References

↑ Lopez S, Rondot L, Cavazza C, Iannello M, Boeri-Erba E, Burzlaff N, Strinitz F, Jorge-Robin A, Marchi-Delapierre C, Menage S. Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme. Chem Commun (Camb). 2017 Mar 23;53(25):3579-3582. doi: 10.1039/c6cc08873b. PMID:28289745 doi:http://dx.doi.org/10.1039/c6cc08873b