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Structural highlights

Function

SPI2B_HUMAN Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846).^{[1] [2]}

See Also

• Spindlin

References

1. ↑ Fletcher BS, Dragstedt C, Notterpek L, Nolan GP. Functional cloning of SPIN-2, a nuclear anti-apoptotic protein with roles in cell cycle progression. Leukemia. 2002 Aug;16(8):1507-18. PMID:12145692 doi:10.1038/sj.leu.2402557
2. ↑ Bae N, Gao M, Li X, Premkumar T, Sbardella G, Chen J, Bedford MT. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017 Dec 22;292(51):20808-20817. PMID:29061846 doi:10.1074/jbc.M117.814913