5xep

Structural highlights

Function

CH3L1_MOUSE Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.^{[1] [2] [3] [4] [5] [6]}

See Also

• Chitinase-3-like protein 3D structures

References

1. ↑ Mizoguchi E. Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells. Gastroenterology. 2006 Feb;130(2):398-411. doi: 10.1053/j.gastro.2005.12.007. PMID:16472595 doi:http://dx.doi.org/10.1053/j.gastro.2005.12.007
2. ↑ Mohanty AK, Fisher AJ, Yu Z, Pradeep MA, Janjanam J, Kaushik JK. Cloning, expression, characterization and crystallization of BRP39, a signalling glycoprotein expressed during mammary gland apoptosis. Protein Expr Purif. 2009 Apr;64(2):213-8. doi: 10.1016/j.pep.2008.11.001. Epub, 2008 Nov 12. PMID:19041398 doi:http://dx.doi.org/10.1016/j.pep.2008.11.001
3. ↑ Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med. 2009 May 11;206(5):1149-66. doi: 10.1084/jem.20081271. Epub 2009 May, 4. PMID:19414556 doi:http://dx.doi.org/10.1084/jem.20081271
4. ↑ Sohn MH, Kang MJ, Matsuura H, Bhandari V, Chen NY, Lee CG, Elias JA. The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. Am J Respir Crit Care Med. 2010 Oct 1;182(7):918-28. doi:, 10.1164/rccm.200912-1793OC. Epub 2010 Jun 17. PMID:20558631 doi:http://dx.doi.org/10.1164/rccm.200912-1793OC
5. ↑ Chen CC, Llado V, Eurich K, Tran HT, Mizoguchi E. Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells. Clin Immunol. 2011 Sep;140(3):268-75. doi: 10.1016/j.clim.2011.04.007. Epub 2011 , Apr 20. PMID:21546314 doi:http://dx.doi.org/10.1016/j.clim.2011.04.007
6. ↑ Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. Cell Host Microbe. 2012 Jul 19;12(1):34-46. doi: 10.1016/j.chom.2012.05.017. PMID:22817986 doi:http://dx.doi.org/10.1016/j.chom.2012.05.017