5ybj

Structural highlights

Disease

KANK1_HUMAN Inherited congenital spastic tetraplegia. The disease is caused by mutations affecting the gene represented in this entry.

Function

KANK1_HUMAN Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.^{[1] [2] [3] [4]}

See Also

• Ankyrin repeat domain-containing protein 3D structures

References

1. ↑ Wang Y, Kakinuma N, Zhu Y, Kiyama R. Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin. J Cell Sci. 2006 Oct 1;119(Pt 19):4002-10. doi: 10.1242/jcs.03169. Epub 2006 Sep , 12. PMID:16968744 doi:http://dx.doi.org/10.1242/jcs.03169
2. ↑ Kakinuma N, Roy BC, Zhu Y, Wang Y, Kiyama R. Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. J Cell Biol. 2008 May 5;181(3):537-49. doi: 10.1083/jcb.200707022. PMID:18458160 doi:http://dx.doi.org/10.1083/jcb.200707022
3. ↑ Roy BC, Kakinuma N, Kiyama R. Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J Cell Biol. 2009 Jan 26;184(2):253-67. doi: 10.1083/jcb.200805147. PMID:19171758 doi:http://dx.doi.org/10.1083/jcb.200805147
4. ↑ Li CC, Kuo JC, Waterman CM, Kiyama R, Moss J, Vaughan M. Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19228-33. doi:, 10.1073/pnas.1117011108. Epub 2011 Nov 14. PMID:22084092 doi:10.1073/pnas.1117011108