5yj3

Structural highlights

Function

TZAP_HUMAN Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).^{[1] [2] [3] [4]}

References

1. ↑ Yoon JH, Choi WI, Jeon BN, Koh DI, Kim MK, Kim MH, Kim J, Hur SS, Kim KS, Hur MW. Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene. J Biol Chem. 2014 Feb 14;289(7):4018-31. doi: 10.1074/jbc.M113.526855. Epub 2014 , Jan 1. PMID:24382891 doi:http://dx.doi.org/10.1074/jbc.M113.526855
2. ↑ Li JS, Miralles Fuste J, Simavorian T, Bartocci C, Tsai J, Karlseder J, Lazzerini Denchi E. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017 Feb 10;355(6325):638-641. doi: 10.1126/science.aah6752. Epub 2017, Jan 12. PMID:28082411 doi:http://dx.doi.org/10.1126/science.aah6752
3. ↑ Jahn A, Rane G, Paszkowski-Rogacz M, Sayols S, Bluhm A, Han CT, Draskovic I, Londono-Vallejo JA, Kumar AP, Buchholz F, Butter F, Kappei D. ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator. EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12. PMID:28500257 doi:http://dx.doi.org/10.15252/embr.201744095
4. ↑ Sugawara M, Scholl T, Ponath PD, Strominger JL. A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein. Mol Cell Biol. 1994 Dec;14(12):8438-50. PMID:7969177