Structural highlights
Function
TPX2_HUMAN Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.[1] [2]
See Also
References
- ↑ Bird AW, Hyman AA. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol. 2008 Jul 28;182(2):289-300. doi: 10.1083/jcb.200802005. PMID:18663142 doi:http://dx.doi.org/10.1083/jcb.200802005
- ↑ Moss DK, Wilde A, Lane JD. Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. J Cell Sci. 2009 Mar 1;122(Pt 5):644-55. doi: 10.1242/jcs.037259. Epub 2009 Feb, 10. PMID:19208764 doi:http://dx.doi.org/10.1242/jcs.037259
