Structural highlights
Function
PRPC_ASPFC Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. Plays a key role in the estabishment of invasive pulmonary aspergillosis.[1]
See Also
References
- ↑ Ibrahim-Granet O, Dubourdeau M, Latge JP, Ave P, Huerre M, Brakhage AA, Brock M. Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol. 2008 Jan;10(1):134-48. doi: 10.1111/j.1462-5822.2007.1025.x. PMID:17973657 doi:http://dx.doi.org/10.1111/j.1462-5822.2007.1025.x
