6eok

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Crystal structure of E. coli L-asparaginase II

Structural highlights

6eok is a 4 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ASPG2_ECOLI

Publication Abstract from PubMed

Resonance assignment and structural characterization of pharmacologically-relevant proteins promises to improve their understanding and safety by rational design. However, the PEG coating that is used to evade the immune system also causes these molecules to "evade" the standard structural biology methodologies. We here demonstrate that it is possible to obtain the resonance assignment and a reliable structural model of large PEGylated proteins through an integrated approach encompassing NMR and X-ray crystallography.

Characterization of PEGylated asparaginase: new opportunities from NMR analysis of large pegylated therapeutics.,Cerofolini L, Giuntini S, Carlon A, Ravera E, Calderone V, Fragai M, Parigi G, Luchinat C Chemistry. 2018 Nov 21. doi: 10.1002/chem.201804488. PMID:30462348[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Cerofolini L, Giuntini S, Carlon A, Ravera E, Calderone V, Fragai M, Parigi G, Luchinat C. Characterization of PEGylated asparaginase: new opportunities from NMR analysis of large pegylated therapeutics. Chemistry. 2018 Nov 21. doi: 10.1002/chem.201804488. PMID:30462348 doi:http://dx.doi.org/10.1002/chem.201804488

Contents


PDB ID 6eok

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