6fzt

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Crystal structure of Smad8_9-MH1 bound to the GGCGC site.

Structural highlights

6fzt is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:GOL, ZN
Gene:SMAD9, MADH6, MADH9, SMAD8 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[SMAD9_HUMAN] Heritable pulmonary arterial hypertension. The disease may be caused by mutations affecting the gene represented in this entry.

Function

[SMAD9_HUMAN] Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Contents


PDB ID 6fzt

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OCA

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