Structural highlights
Function
WDR6_YEAST Involved in regulation of Ty1 transposition. Plays also a role in the regulation of the retromer complex and is required for the recycling from endosomes of plasma membrane proteins like CAN1 and MUP1. Required together with TRM7 for the methylation of the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)).[1] [2] [3]
See Also
References
- ↑ Nyswaner KM, Checkley MA, Yi M, Stephens RM, Garfinkel DJ. Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis. Genetics. 2008 Jan;178(1):197-214. doi: 10.1534/genetics.107.082602. PMID:18202368 doi:http://dx.doi.org/10.1534/genetics.107.082602
- ↑ Shi Y, Stefan CJ, Rue SM, Teis D, Emr SD. Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell. 2011 Nov;22(21):4093-107. doi: 10.1091/mbc.E11-05-0440. Epub 2011 , Aug 31. PMID:21880895 doi:http://dx.doi.org/10.1091/mbc.E11-05-0440
- ↑ Guy MP, Podyma BM, Preston MA, Shaheen HH, Krivos KL, Limbach PA, Hopper AK, Phizicky EM. Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. RNA. 2012 Oct;18(10):1921-33. doi: 10.1261/rna.035287.112. Epub 2012 Aug 21. PMID:22912484 doi:http://dx.doi.org/10.1261/rna.035287.112
