Structural highlights
Function
CNTK_STAAM Catalyzes the reversible interconversion of the L- and D-stereoisomers of histidine. Functions in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, cobalt, zinc, copper, and iron, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to staphylococcal virulence. Appears to be specific for histidine, as it cannot use L-alanine and L-methionine as substrate.[1]
References
- ↑ Ghssein G, Brutesco C, Ouerdane L, Fojcik C, Izaute A, Wang S, Hajjar C, Lobinski R, Lemaire D, Richaud P, Voulhoux R, Espaillat A, Cava F, Pignol D, Borezée-Durant E, Arnoux P. Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus. Science. 2016 May 27;352(6289):1105-9. PMID:27230378 doi:10.1126/science.aaf1018
