6m02

Structural highlights

Function

[PANX1_HUMAN] Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.^{[1] [2]}

References

1. ↑ Vanden Abeele F, Bidaux G, Gordienko D, Beck B, Panchin YV, Baranova AV, Ivanov DV, Skryma R, Prevarskaya N. Functional implications of calcium permeability of the channel formed by pannexin 1. J Cell Biol. 2006 Aug 14;174(4):535-46. doi: 10.1083/jcb.200601115. PMID:16908669 doi:http://dx.doi.org/10.1083/jcb.200601115
2. ↑ Bunse S, Schmidt M, Prochnow N, Zoidl G, Dermietzel R. Intracellular cysteine 346 is essentially involved in regulating Panx1 channel activity. J Biol Chem. 2010 Dec 3;285(49):38444-52. doi: 10.1074/jbc.M110.101014. Epub 2010, Sep 9. PMID:20829356 doi:http://dx.doi.org/10.1074/jbc.M110.101014