6m36

Structural highlights

Function

RSBW_BACSU Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).^{[1] [2] [3]}

See Also

• Anti-sigma factor antagonist 3D structures

References

1. ↑ Boylan SA, Rutherford A, Thomas SM, Price CW. Activation of Bacillus subtilis transcription factor sigma B by a regulatory pathway responsive to stationary-phase signals. J Bacteriol. 1992 Jun;174(11):3695-706. PMID:1592822
2. ↑ Dufour A, Haldenwang WG. Interactions between a Bacillus subtilis anti-sigma factor (RsbW) and its antagonist (RsbV). J Bacteriol. 1994 Apr;176(7):1813-20. PMID:8144446 doi:10.1128/jb.176.7.1813-1820.1994
3. ↑ Benson AK, Haldenwang WG. Regulation of sigma B levels and activity in Bacillus subtilis. J Bacteriol. 1993 Apr;175(8):2347-56. PMID:8468294