6ti3

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Apo-SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with D-Threonine

Structural highlights

6ti3 is a 4 chain structure with sequence from Streptococcus thermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.96Å
Ligands:DTH, GOL, NA
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLYA_STRT1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

See Also

Contents


PDB ID 6ti3

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OCA

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