6tm1

From Proteopedia

Jump to: navigation, search

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

Structural highlights

6tm1 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.71Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAC3_HUMAN Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.[1]

See Also

References

  1. ↑ De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002 May;9(5):451-9. PMID:11956649

Contents


PDB ID 6tm1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/6tm1"
Personal tools