6tnp

From Proteopedia

Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide

Structural highlights

6tnp is a 12 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3Å
Ligands:	NO8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.,Macias-Leon J, Bermejo IA, Asin A, Garcia-Garcia A, Companon I, Jimenez-Moreno E, Coelho H, Mangini V, Albuquerque IS, Marcelo F, Asensio JL, Bernardes GJL, Joshi HJ, Fiammengo R, Blixt O, Hurtado-Guerrero R, Corzana F Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. doi: 10.1039/d0cc06349e. PMID:33211039^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

3 reviews cite this structure

Advances in MUC1-Mediated Breast Cancer Immunotherapy.

Li et al. (2022)

2 more

4 other articles

No citations found

References

↑ Macías-León J, Bermejo IA, Asín A, García-García A, Compañón I, Jiménez-Moreno E, Coelho H, Mangini V, Albuquerque IS, Marcelo F, Asensio JL, Bernardes GJL, Joshi HJ, Fiammengo R, Blixt O, Hurtado-Guerrero R, Corzana F. Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody. Chem Commun (Camb). 2020 Dec 8;56(96):15137-15140. PMID:33211039 doi:10.1039/d0cc06349e

1 Structural highlights
2 Publication Abstract from PubMed
3 See Also
4 References

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PDB ID 6tnp

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Categories: Large Structures | Mus musculus | Corzana F | Hurtado-Guerrero R | Macias-Leon J

6tnp

From Proteopedia

Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide

Structural highlights

Publication Abstract from PubMed

See Also

References

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