6whb

From Proteopedia

MEKK1 TOG domain (548-867)

Structural highlights

6whb is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9003205Å
Ligands:	ACT, GOL
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

M3K1_HUMAN 46,XY partial gonadal dysgenesis;46,XY complete gonadal dysgenesis. The disease is caused by mutations affecting the gene represented in this entry.

Function

M3K1_HUMAN Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).^[1] ^[2]

References

↑ Ye B, Yu WP, Thomas GM, Huganir RL. GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. FEBS Lett. 2007 Sep 18;581(23):4403-10. doi: 10.1016/j.febslet.2007.08.008. Epub , 2007 Aug 14. PMID:17761173 doi:http://dx.doi.org/10.1016/j.febslet.2007.08.008
↑ Xia Y, Wu Z, Su B, Murray B, Karin M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 1998 Nov 1;12(21):3369-81. doi: 10.1101/gad.12.21.3369. PMID:9808624 doi:http://dx.doi.org/10.1101/gad.12.21.3369