6zqd

Structural highlights

Function

UTP8_YEAST Involved in nucleolar processing of pre-18S ribosomal RNA. Also has a role in nuclear tRNA export. It acts between the steps of tRNA maturation/aminoacylation and its subsequent translocation out of the nucleus. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).^{[1] [2] [3]}

See Also

• Adenosine dimethyltransferase 3D structures
• Ribosome 3D structures
• Ribosome biogenesis protein 3D structures

References

1. ↑ Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA, Wehner KA, Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, Beyer AL, Hunt DF, Baserga SJ. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature. 2002 Jun 27;417(6892):967-70. Epub 2002 Jun 9. PMID:12068309 doi:http://dx.doi.org/10.1038/nature00769
2. ↑ Steiner-Mosonyi M, Leslie DM, Dehghani H, Aitchison JD, Mangroo D. Utp8p is an essential intranuclear component of the nuclear tRNA export machinery of Saccharomyces cerevisiae. J Biol Chem. 2003 Aug 22;278(34):32236-45. PMID:12794079 doi:10.1074/jbc.M302779200
3. ↑ Gallagher JE, Dunbar DA, Granneman S, Mitchell BM, Osheim Y, Beyer AL, Baserga SJ. RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev. 2004 Oct 15;18(20):2506-17. PMID:15489292 doi:http://dx.doi.org/18/20/2506