Structural highlights
Function
GFRP_HUMAN Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.[1]
References
- ↑ Chavan B, Gillbro JM, Rokos H, Schallreuter KU. GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. J Invest Dermatol. 2006 Nov;126(11):2481-9. Epub 2006 Jun 15. PMID:16778797 doi:http://dx.doi.org/5700425