7cm3

Structural highlights

Disease

NALCN_HUMAN Freeman-Sheldon syndrome;Congenital limbs-face contractures-hypotonia-developmental delay syndrome;Distal arthrogryposis type 1;Hypotonia-speech impairment-severe cognitive delay syndrome;Sheldon-Hall syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

Function

NALCN_HUMAN Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:17448995, PubMed:31409833). NALCN channel functions as a multi-protein complex, which consists at least of NALCN, NALF1, UNC79 and UNC80 (PubMed:32494638, PubMed:33203861). NALCN is the voltage-sensing, pore-forming subunit of the NALCN channel complex (PubMed:17448995). NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal (By similarity). NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway (By similarity). In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity).[UniProtKB:Q8BXR5]^{[1] [2] [3] [4]}

References

1. ↑ Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 2007 Apr 20;129(2):371-83. PMID:17448995 doi:10.1016/j.cell.2007.02.041
2. ↑ Bouasse M, Impheng H, Servant Z, Lory P, Monteil A. Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN Sci Rep. 2019 Aug 13;9(1):11791. PMID:31409833 doi:10.1038/s41598-019-48071-x
3. ↑ Chua HC, Wulf M, Weidling C, Rasmussen LP, Pless SA. The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium. Sci Adv. 2020 Apr 24;6(17):eaaz3154. PMID:32494638 doi:10.1126/sciadv.aaz3154
4. ↑ Xie J, Ke M, Xu L, Lin S, Huang J, Zhang J, Yang F, Wu J, Yan Z. Structure of the human sodium leak channel NALCN in complex with FAM155A. Nat Commun. 2020 Nov 17;11(1):5831. PMID:33203861 doi:10.1038/s41467-020-19667-z