7cq6

From Proteopedia

Structure of the human CLCN7-OSTM1 complex

Structural highlights

7cq6 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3Å
Ligands:	CL, NAG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

OSTM1_HUMAN Infantile osteopetrosis with neuroaxonal dysplasia. The disease is caused by variants affecting the gene represented in this entry.

Function

OSTM1_HUMAN Required for osteoclast and melanocyte maturation and function.^[1]

References

↑ Leisle L, Ludwig CF, Wagner FA, Jentsch TJ, Stauber T. ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires Ostm1 for transport activity. EMBO J. 2011 Jun 1;30(11):2140-52. PMID:21527911 doi:10.1038/emboj.2011.137

1 Structural highlights
2 Disease
3 Function
4 See Also
5 References

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PDB ID 7cq6

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7cq6

From Proteopedia

Structure of the human CLCN7-OSTM1 complex

Structural highlights

Disease

Function

See Also

References

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