7cyi

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Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua

Structural highlights

7cyi is a 4 chain structure with sequence from Artemisia annua. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.95Å
Ligands:ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ADH1_ARTAN Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:23575629, PubMed:27488942). Catalyzes the conversion of artemisinic alcohol into artemisinic aldehyde (PubMed:23575629).[1] [2]

See Also

References

  1. ↑ Paddon CJ, Westfall PJ, Pitera DJ, Benjamin K, Fisher K, McPhee D, Leavell MD, Tai A, Main A, Eng D, Polichuk DR, Teoh KH, Reed DW, Treynor T, Lenihan J, Fleck M, Bajad S, Dang G, Dengrove D, Diola D, Dorin G, Ellens KW, Fickes S, Galazzo J, Gaucher SP, Geistlinger T, Henry R, Hepp M, Horning T, Iqbal T, Jiang H, Kizer L, Lieu B, Melis D, Moss N, Regentin R, Secrest S, Tsuruta H, Vazquez R, Westblade LF, Xu L, Yu M, Zhang Y, Zhao L, Lievense J, Covello PS, Keasling JD, Reiling KK, Renninger NS, Newman JD. High-level semi-synthetic production of the potent antimalarial artemisinin. Nature. 2013 Apr 25;496(7446):528-32. PMID:23575629 doi:10.1038/nature12051
  2. ↑ Tu Y. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture). Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10210-26. PMID:27488942 doi:10.1002/anie.201601967

Contents


PDB ID 7cyi

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