7dpa

From Proteopedia

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex

Structural highlights

7dpa is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DOCK5_HUMAN Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).[UniProtKB:B2RY04]^[1]

References

↑ Sanders MA, Ampasala D, Basson MD. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J Biol Chem. 2009 Jan 2;284(1):27-35. PMID:19004829 doi:10.1074/jbc.M808010200

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 7dpa

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7dpa

From Proteopedia

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex

Structural highlights

Function

See Also

References

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