7ewm

From Proteopedia

Native crystal structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1

Structural highlights

7ewm is a 3 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

THP3_YEAST Forms a complex with CSN12 that is recruited to transcribed genes and required for transcription elongation. May also be involved in pre-mRNA splicing.^[1] ^[2] ^[3]

References

↑ Wilmes GM, Bergkessel M, Bandyopadhyay S, Shales M, Braberg H, Cagney G, Collins SR, Whitworth GB, Kress TL, Weissman JS, Ideker T, Guthrie C, Krogan NJ. A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell. 2008 Dec 5;32(5):735-46. doi: 10.1016/j.molcel.2008.11.012. PMID:19061648 doi:http://dx.doi.org/10.1016/j.molcel.2008.11.012
↑ Faza MB, Kemmler S, Jimeno S, Gonzalez-Aguilera C, Aguilera A, Hurt E, Panse VG. Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery. J Cell Biol. 2009 Mar 23;184(6):833-46. doi: 10.1083/jcb.200810059. Epub 2009 Mar, 16. PMID:19289793 doi:http://dx.doi.org/10.1083/jcb.200810059
↑ Jimeno S, Tous C, Garcia-Rubio ML, Ranes M, Gonzalez-Aguilera C, Marin A, Aguilera A. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Mol Cell Biol. 2011 Feb;31(4):674-85. doi: 10.1128/MCB.01188-10. Epub 2010 Dec, 13. PMID:21149575 doi:http://dx.doi.org/10.1128/MCB.01188-10