7l29

From Proteopedia

Crystal structure of the catalytic domain of human PDE3A bound to AMP

Structural highlights

7l29 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.08Å
Ligands:	ACT, AMP, CA, MG, MN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

PDE3A_HUMAN Brachydactyly-arterial hypertension syndrome. The disease is caused by variants affecting the gene represented in this entry.

Function

PDE3A_HUMAN Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.[UniProtKB:Q9Z0X4]

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PDB ID 7l29

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Categories: Homo sapiens | Large Structures | Garvie C | Horner SW

7l29

From Proteopedia

Crystal structure of the catalytic domain of human PDE3A bound to AMP

Structural highlights

Disease

Function

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