Structural highlights
Function
FRDA_DROME Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways (PubMed:18540637). May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+) (PubMed:18540637). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (PubMed:18540637). Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition (PubMed:25628335).[1] [2]
See Also
References
- ↑ Kondapalli KC, Kok NM, Dancis A, Stemmler TL. Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly. Biochemistry. 2008 Jul 1;47(26):6917-27. doi: 10.1021/bi800366d. Epub 2008 Jun , 10. PMID:18540637 doi:http://dx.doi.org/10.1021/bi800366d
- ↑ Palandri A, L'hôte D, Cohen-Tannoudji J, Tricoire H, Monnier V. Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells. Hum Mol Genet. 2015 May 1;24(9):2615-26. PMID:25628335 doi:10.1093/hmg/ddv024
