Structural highlights
Function
RNAS1_BOVIN Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.[1]
Publication Abstract from PubMed
X-ray diffraction data demonstrate that the adduct formed upon the reaction of dirhodium(II,II) tetraacetate with RNase A reacts with imidazole, leading to the formation of an unexpected product with the imidazole that binds the dirhodium center at an equatorial site rather than an axial site. The origin of this result has been dissected using quantum-chemical calculations.
Unexpected Imidazole Coordination to the Dirhodium Center in a Protein Environment: Insights from X-ray Crystallography and Quantum Chemistry.,Loreto D, Fasulo F, Munoz-Garcia AB, Pavone M, Merlino A Inorg Chem. 2022 Jun 6;61(22):8402-8405. doi: 10.1021/acs.inorgchem.2c01370. Epub, 2022 May 24. PMID:35609175[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688
- ↑ Loreto D, Fasulo F, Munoz-Garcia AB, Pavone M, Merlino A. Unexpected Imidazole Coordination to the Dirhodium Center in a Protein Environment: Insights from X-ray Crystallography and Quantum Chemistry. Inorg Chem. 2022 Jun 6;61(22):8402-8405. doi: 10.1021/acs.inorgchem.2c01370. Epub, 2022 May 24. PMID:35609175 doi:http://dx.doi.org/10.1021/acs.inorgchem.2c01370
