7qvm

From Proteopedia

Jump to: navigation, search

Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex

Structural highlights

7qvm is a 6 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.25Å
Ligands:NH2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

GNAO_HUMAN Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

GNAO_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

Publication Abstract from PubMed

The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.

Structural basis for the activation and ligand recognition of the human oxytocin receptor.,Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A Nat Commun. 2022 Jul 18;13(1):4153. doi: 10.1038/s41467-022-31325-0. PMID:35851571[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Loading citation details..
Citations
1 reviews cite this structure
Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers.
Kalaba et al. (2024)
0 more
5 other articles
No citations found

See Also

References

  1. ↑ Waltenspühl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Plückthun A. Structural basis for the activation and ligand recognition of the human oxytocin receptor. Nat Commun. 2022 Jul 18;13(1):4153. PMID:35851571 doi:10.1038/s41467-022-31325-0

Contents


PDB ID 7qvm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/7qvm"
Personal tools