7t6f

From Proteopedia

Jump to: navigation, search

Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain

Structural highlights

7t6f is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.6Å
Ligands:ADN, ADP
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

JAK1_MOUSE Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors.[UniProtKB:P23458]

See Also

Contents


PDB ID 7t6f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://proteopedia.org/wiki/index.php/7t6f"
Personal tools