7tva

From Proteopedia

Stat5a Core in complex with AK2292

Structural highlights

7tva is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.835Å
Ligands:	KOO, MLI, PEG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

STA5A_HUMAN Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.^[1]

References

↑ Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol. 2004 Nov 8;167(3):469-78. PMID:15534001 doi:10.1083/jcb.200403155

1 Structural highlights
2 Function
3 References

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PDB ID 7tva

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Categories: Homo sapiens | Large Structures | Meagher JL | Stuckey JA

7tva

From Proteopedia

Stat5a Core in complex with AK2292

Structural highlights

Function

References

Contents

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