Structural highlights
Disease
TOM40_HUMAN Early-onset autosomal dominant Alzheimer disease.
Function
TOM20_HUMAN Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).TOM40_HUMAN Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022).[1] [2]
References
- ↑ Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, Ryan MT. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005 Mar 25;280(12):11535-43. PMID:15644312 doi:10.1074/jbc.M413816200
- ↑ Namba T. BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Sci Adv. 2019 Jun 12;5(6):eaaw1386. PMID:31206022 doi:10.1126/sciadv.aaw1386
