7vtx

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Crystal structure of PDE8A catalytic domain in complex with 22

Structural highlights

7vtx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5001094Å
Ligands:80D, MG, ZN
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE8A_HUMAN Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.[1]

See Also

References

  1. ↑ Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H. Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity. Biochemistry. 2008 Nov 5. PMID:18983167 doi:10.1021/bi801487x

Contents


PDB ID 7vtx

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OCA

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