Structural highlights
Function
IRTA_MYCTU Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Mycobactins are then reduced by the siderophore interaction domain to facilitate iron release in the bacterial cell (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF5][1] [2]
References
- ↑ Rodriguez GM, Smith I. Identification of an ABC transporter required for iron acquisition and virulence in Mycobacterium tuberculosis. J Bacteriol. 2006 Jan;188(2):424-30. doi: 10.1128/JB.188.2.424-430.2006. PMID:16385031 doi:http://dx.doi.org/10.1128/JB.188.2.424-430.2006
- ↑ Ryndak MB, Wang S, Smith I, Rodriguez GM. The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain. J Bacteriol. 2010 Feb;192(3):861-9. doi: 10.1128/JB.00223-09. Epub 2009 Nov 30. PMID:19948799 doi:http://dx.doi.org/10.1128/JB.00223-09
