7wnu

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Mycobacterium tuberculosis Rnase J complex with 7nt RNA

Structural highlights

7wnu is a 4 chain structure with sequence from Mycobacterium tuberculosis H37Rv and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.2Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RNJ_MYCTU An RNase that has 5'-3' exonuclease and possible endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity). Has both beta-lactamase and RNase activity, but the physiological relevance of the beta-lactamase activity, i.e. whether it confers antibiotic resistance, has not been shown (PubMed:21568871).[1]

See Also

References

  1. ↑ Sun L, Zhang L, Zhang H, He ZG. Characterization of a bifunctional beta-lactamase/ribonuclease and its interaction with a chaperone-like protein in the pathogen Mycobacterium tuberculosis H37Rv. Biochemistry (Mosc). 2011 Mar;76(3):350-8. doi: 10.1134/s0006297911030096. PMID:21568871 doi:http://dx.doi.org/10.1134/s0006297911030096

Contents


PDB ID 7wnu

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OCA

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