7yz7

From Proteopedia

Crystal structure of the zebrafish FoxH1 bound to the TGTGGATT site

Structural highlights

7yz7 is a 3 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 0.98Å
Ligands:	K
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FOXH1_DANRE Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry.^[1] ^[2]

References

↑ Pogoda HM, Solnica-Krezel L, Driever W, Meyer D. The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation. Curr Biol. 2000 Sep 7;10(17):1041-9. PMID:10996071
↑ Sirotkin HI, Gates MA, Kelly PD, Schier AF, Talbot WS. Fast1 is required for the development of dorsal axial structures in zebrafish. Curr Biol. 2000 Sep 7;10(17):1051-4. doi: 10.1016/s0960-9822(00)00679-5. PMID:10996072 doi:http://dx.doi.org/10.1016/s0960-9822(00)00679-5

1 Structural highlights
2 Function
3 See Also
4 References

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PDB ID 7yz7

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Categories: Danio rerio | Large Structures | Macias MJ | Pluta R

7yz7

From Proteopedia

Crystal structure of the zebrafish FoxH1 bound to the TGTGGATT site

Structural highlights

Function

See Also

References

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