7zam

Structural highlights

Function

KHDR1_HUMAN Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.^{[1] [2] [3] [4]} [UniProtKB:Q60749][UniProtKB:Q8UUW7] Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.^{[5] [6] [7]}

References

1. ↑ Barlat I, Maurier F, Duchesne M, Guitard E, Tocque B, Schweighoffer F. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain. J Biol Chem. 1997 Feb 7;272(6):3129-32. PMID:9013542
2. ↑ Fusaki N, Iwamatsu A, Iwashima M, Fujisawa Ji. Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. J Biol Chem. 1997 Mar 7;272(10):6214-9. PMID:9045636
3. ↑ Sanchez-Margalet V, Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol. 2001 Jul 10;211(1):30-6. PMID:11585385 doi:10.1006/cimm.2001.1815
4. ↑ Wong G, Muller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F. Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell. 1992 May 1;69(3):551-8. PMID:1374686
5. ↑ Barlat I, Maurier F, Duchesne M, Guitard E, Tocque B, Schweighoffer F. A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain. J Biol Chem. 1997 Feb 7;272(6):3129-32. PMID:9013542
6. ↑ Fusaki N, Iwamatsu A, Iwashima M, Fujisawa Ji. Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling. J Biol Chem. 1997 Mar 7;272(10):6214-9. PMID:9045636
7. ↑ Sanchez-Margalet V, Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol. 2001 Jul 10;211(1):30-6. PMID:11585385 doi:10.1006/cimm.2001.1815