7zlr

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Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13

Structural highlights

7zlr is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.01Å
Ligands:JH9
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SOCS2_HUMAN SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Contents


PDB ID 7zlr

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OCA

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