8amr | pdb_00008amr

Coiled-coil domain of human TRIM3

Structural highlights

8amr is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.8Å
Ligands:	GOL, PE8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TRIM3_HUMAN E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999).[UniProtKB:Q9R1R2]^[1] ^[2] ^[3]

References

↑ Yan Q, Sun W, Kujala P, Lotfi Y, Vida TA, Bean AJ. CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. Mol Biol Cell. 2005 May;16(5):2470-82. Epub 2005 Mar 16. PMID:15772161 doi:https://dx.doi.org/E04-11-1014
↑ Raheja R, Liu Y, Hukkelhoven E, Yeh N, Koff A. The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J. 2014 Mar 15;458(3):537-45. PMID:24393003 doi:10.1042/BJ20131288
↑ Li WW, Nie Y, Yang Y, Ran Y, Luo WW, Xiong MG, Wang SY, Xu ZS, Wang YY. Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23707-23716. PMID:32878999 doi:10.1073/pnas.2002472117

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OCA

[1] Yan Q, Sun W, Kujala P, Lotfi Y, Vida TA, Bean AJ. CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling. Mol Biol Cell. 2005 May;16(5):2470-82. Epub 2005 Mar 16. PMID:15772161 doi:https://dx.doi.org/E04-11-1014

[2] Raheja R, Liu Y, Hukkelhoven E, Yeh N, Koff A. The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity. Biochem J. 2014 Mar 15;458(3):537-45. PMID:24393003 doi:10.1042/BJ20131288

[3] Li WW, Nie Y, Yang Y, Ran Y, Luo WW, Xiong MG, Wang SY, Xu ZS, Wang YY. Ubiquitination of TLR3 by TRIM3 signals its ESCRT-mediated trafficking to the endolysosomes for innate antiviral response. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23707-23716. PMID:32878999 doi:10.1073/pnas.2002472117

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[3]

8amr | pdb_00008amr

Coiled-coil domain of human TRIM3

Structural highlights

Function

References

Contents

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