8blp

From Proteopedia

Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14

Structural highlights

8blp is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.6Å
Ligands:	5D3, LMT, PTY, Y01
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UT1_HUMAN Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.

1 Structural highlights
2 Function

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PDB ID 8blp

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8blp

From Proteopedia

Human Urea Transporter UT-B/UT1 in Complex with Inhibitor UTBinh-14

Structural highlights

Function

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