8d1h

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hBest2 Ca2+-unbound closed state

Structural highlights

8d1h is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 1.94Å
Ligands:CL, DU0, MC3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BEST2_HUMAN Forms calcium-sensitive chloride channels. Permeable to bicarbonate.[1] [2] [3]

See Also

References

  1. Sun H, Tsunenari T, Yau KW, Nathans J. The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4008-13. doi: 10.1073/pnas.052692999. PMID:11904445 doi:http://dx.doi.org/10.1073/pnas.052692999
  2. Tsunenari T, Sun H, Williams J, Cahill H, Smallwood P, Yau KW, Nathans J. Structure-function analysis of the bestrophin family of anion channels. J Biol Chem. 2003 Oct 17;278(42):41114-25. doi: 10.1074/jbc.M306150200. Epub 2003, Aug 7. PMID:12907679 doi:http://dx.doi.org/10.1074/jbc.M306150200
  3. Qu Z, Hartzell HC. Bestrophin Cl- channels are highly permeable to HCO3-. Am J Physiol Cell Physiol. 2008 Jun;294(6):C1371-7. doi:, 10.1152/ajpcell.00398.2007. Epub 2008 Apr 9. PMID:18400985 doi:http://dx.doi.org/10.1152/ajpcell.00398.2007

Contents


PDB ID 8d1h

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