8e06

From Proteopedia

Symmetry expansion of dimeric LRRK1

Structural highlights

8e06 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4.3Å
Ligands:	GDP
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

LRRK1_HUMAN Osteosclerotic metaphyseal dysplasia. The disease is caused by variants affecting the gene represented in this entry.

Function

LRRK1_HUMAN Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.[UniProtKB:Q3UHC2]

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PDB ID 8e06

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Categories: Homo sapiens | Large Structures | Leschziner AE | Lin YX | Reimer JM

8e06

From Proteopedia

Symmetry expansion of dimeric LRRK1

Structural highlights

Disease

Function

See Also

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