8gva

Structural highlights

Function

B3A2_HUMAN Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).[UniProtKB:P13808]^{[1] [2]}

References

1. ↑ Aranda V, Martínez I, Melero S, Lecanda J, Banales JM, Prieto J, Medina JF. Shared apical sorting of anion exchanger isoforms AE2a, AE2b1, and AE2b2 in primary hepatocytes. Biochem Biophys Res Commun. 2004 Jul 2;319(3):1040-6. PMID:15184086 doi:10.1016/j.bbrc.2004.05.080
2. ↑ Xue JY, Grigelioniene G, Wang Z, Nishimura G, Iida A, Matsumoto N, Tham E, Miyake N, Ikegawa S, Guo L. SLC4A2 Deficiency Causes a New Type of Osteopetrosis. J Bone Miner Res. 2022 Feb;37(2):226-235. PMID:34668226 doi:10.1002/jbmr.4462