8j19

From Proteopedia

Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex

Structural highlights

8j19 is a 5 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.23Å
Ligands:	SWO
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GPR84_HUMAN Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.^[1]

References

↑ Wang J, Wu X, Simonavicius N, Tian H, Ling L. Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem. 2006 Nov 10;281(45):34457-64. PMID:16966319 doi:10.1074/jbc.M608019200

1 Structural highlights
2 Function
3 References

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PDB ID 8j19

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8j19

From Proteopedia

Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex

Structural highlights

Function

References

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