8ov6

From Proteopedia

Ternary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPB

Structural highlights

8ov6 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.77Å
Ligands:	U79, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCA16_HUMAN Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.^[1] ^[2]

References

↑ Jin J, Arias EE, Chen J, Harper JW, Walter JC. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell. 2006 Sep 1;23(5):709-21. PMID:16949367 doi:http://dx.doi.org/S1097-2765(06)00570-3
↑ Zhang X, Crowley VM, Wucherpfennig TG, Dix MM, Cravatt BF. Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nat Chem Biol. 2019 Jul;15(7):737-746. PMID:31209349 doi:10.1038/s41589-019-0279-5

1 Structural highlights
2 Function
3 References

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PDB ID 8ov6

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8ov6

From Proteopedia

Ternary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPB

Structural highlights

Function

References

Contents

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